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Benign neoplasm of ovary

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_OVARY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D27
  • Hospital discharge: ICD-9 — 220
  • Hospital discharge: ICD-8 — 220
  • Cause of death: ICD-10 — D27
  • Cause of death: ICD-9 — 220
  • Cause of death: ICD-8 — 220

2 out of 7 registries used, show all original rules.

6533

4. Check minimum number of events

None

6533

5. Include endpoints

None

6533

6. Filter based on genotype QC (FinnGen only)

6323

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Neoplasma benignum ovarii

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 54106 54106 -
Only index persons 48104 48104 -
Unadjusted period prevalence (%)
Whole population 1.55 1.55 -
Only index persons 1.77 1.77 -
Median age at first event (years)
Whole population - 43.07 -
Only index persons - 41.59 -

-FinnGen-

Key figures

All Female Male
Number of individuals 6323 6323 -
Unadjusted period prevalence (%) 2.48 2.48 -
Median age at first event (years) 40.24 40.24 -

-FinRegistry-

Age distribution of first events

01020304050607080900k1k2k3k4k5k6k7k8k9k10k11k12kAgeIndividuals

-FinnGen-

Age distribution of first events

010203040506070800.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k1k2k3k4k5k6k7k8kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230100200300400500600700800YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.02.22.42.62.83.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.0AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint CD2_BENIGN_OVARY and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_OVARY 1.156 [1.06, 1.26] < 0.001
Birth year 0.996 [0.99, 1.0] 0.318

During the follow-up period (1.1.1998 — 31.12.2019), 2472 out of 17767 females with CD2_BENIGN_OVARY died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_OVARY.

N-year risk Females Males
1 0.095% No data
5 0.651% No data
10 1.708% No data
15 3.314% No data
20 5.987% No data

Relationships between endpoints

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Index endpoint: CD2_BENIGN_OVARY – Benign neoplasm of ovary

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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