benign neoplasm: A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
513 |
4. Check minimum number of eventsNone |
513 |
5. Include endpointsNone |
513 |
6. Filter based on genotype QC (FinnGen only) |
500 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Other/unspecified site
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Other/unspecified site
- Benign neoplasm of other and unspecified sites
- Benign neoplasm of other and unspecified sites
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4683 | 2655 | 1987 |
| Only index persons | 3950 | 2292 | 1658 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.06 |
| Only index persons | 0.08 | 0.08 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 51.34 | 50.73 | 51.95 |
| Only index persons | 48.91 | 48.60 | 49.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 500 | 288 | 212 |
| Unadjusted period prevalence (%) | 0.11 | 0.11 | 0.11 |
| Median age at first event (years) | 48.44 | 44.17 | 54.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_NOS | 1.162 [1.01, 1.34] | 0.041 |
| Birth year | 0.996 [0.99, 1.0] | 0.306 |
During the follow-up period (1.1.1998 — 31.12.2019), 364 out of 1726 females with CD2_BENIGN_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_NOS | 1.229 [1.03, 1.46] | 0.02 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 353 out of 1351 males with CD2_BENIGN_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.241% |
| 5 | 0.732% | 1.341% |
| 10 | 1.722% | 3.462% |
| 15 | 3.384% | 6.531% |
| 20 | 6.018% | 10.979% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_NOS – Benign neoplasm: Other/unspecified site
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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