Benign neoplasm: Lymph nodes

CD2_BENIGN_LYMPHNODES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D36.0&
  • Hospital discharge: ICD-9 2298A
  • Cause of death: ICD-10 D36.0&
  • Cause of death: ICD-9 2298A

2 out of 7 registries used, show all original rules.

87

4. Check minimum number of events

None

87

5. Include endpoints

None

87

6. Filter based on genotype QC (FinnGen only)

85

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D36
Name in latin Neoplasma benignum lymphonodorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 852 474 370
Only index persons 714 415 299
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 49.64 50.35 48.54
Only index persons 47.74 49.63 45.12

-FinnGen-

Key figures

All Female Male
Number of individuals 85 58 27
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 48.29 46.00 53.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_LYMPHNODES and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_LYMPHNODES 1.777 [1.35, 2.34] < 0.001
Birth year 1.0 [0.99, 1.01] 0.901

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 393 females with CD2_BENIGN_LYMPHNODES died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_LYMPHNODES 2.227 [1.65, 3.0] < 0.001
Birth year 0.99 [0.98, 1.0] 0.086

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 327 males with CD2_BENIGN_LYMPHNODES died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LYMPHNODES.

N-year risk Females Males
1 0.232% 0.424%
5 1.325% 2.999%
10 3.068% 7.057%
15 5.479% 13.282%
20 9.918% 22.164%

Relationships between endpoints

Index endpoint: CD2_BENIGN_LYMPHNODES – Benign neoplasm: Lymph nodes

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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