Lymphangioma, anys site

CD2_BENIGN_LYMPHANGIOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D18.1&
  • Hospital discharge: ICD-9 2281
  • Hospital discharge: ICD-8 22701
  • Cause of death: ICD-10 D18.1&
  • Cause of death: ICD-9 2281
  • Cause of death: ICD-8 22701

2 out of 7 registries used, show all original rules.

256

4. Check minimum number of events

None

256

5. Include endpoints

None

256

6. Filter based on genotype QC (FinnGen only)

250

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D18
Name in latin Lymphangioma (quovis hoco)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2976 1458 1511
Only index persons 2551 1253 1298
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 16.06 17.67 14.29
Only index persons 18.56 20.72 16.47

-FinnGen-

Key figures

All Female Male
Number of individuals 250 153 97
Unadjusted period prevalence (%) 0.06 0.06 0.05
Median age at first event (years) 32.41 32.83 31.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_LYMPHANGIOMA and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_LYMPHANGIOMA 1.448 [1.07, 1.96] 0.017
Birth year 0.992 [0.98, 1.0] 0.092

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 980 females with CD2_BENIGN_LYMPHANGIOMA died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_LYMPHANGIOMA 1.548 [1.15, 2.08] 0.004
Birth year 0.985 [0.97, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 1096 males with CD2_BENIGN_LYMPHANGIOMA died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LYMPHANGIOMA.

N-year risk Females Males
1 0.107% 0.272%
5 0.651% 1.425%
10 1.786% 3.827%
15 3.482% 7.045%
20 6.277% 12.193%

Relationships between endpoints

Index endpoint: CD2_BENIGN_LYMPHANGIOMA – Lymphangioma, anys site

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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