uterine fibroid: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
39353 |
4. Check minimum number of eventsNone |
39353 |
5. Include endpointsNone |
39353 |
6. Filter based on genotype QC (FinnGen only) |
37952 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Leiomyoma uteri
Similar endpoints
↥List of similar endpoints to
Leiomyoma of uterus
based on the number of shared cases.
Similar with more cases:
- Leiomyoma of uterus
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 302635 | 302635 | - |
| Only index persons | 283123 | 283123 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.67 | 8.67 | - |
| Only index persons | 10.41 | 10.41 | - |
| Median age at first event (years) | |||
| Whole population | - | 46.91 | - |
| Only index persons | - | 46.75 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 37952 | 37952 | - |
| Unadjusted period prevalence (%) | 14.91 | 14.91 | - |
| Median age at first event (years) | 46.68 | 46.68 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_LEIOMYOMA_UTERI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LEIOMYOMA_UTERI | 0.867 [0.8, 0.94] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 9080 out of 138246 females with CD2_BENIGN_LEIOMYOMA_UTERI died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_LEIOMYOMA_UTERI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.076% | No data |
| 5 | 0.498% | No data |
| 10 | 1.288% | No data |
| 15 | 2.456% | No data |
| 20 | 4.441% | No data |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_LEIOMYOMA_UTERI – Leiomyoma of uterus
GWS hits: 105
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data