Benign neoplasm of other and unspecified intrathoracic organs

CD2_BENIGN_INTRATHORACIC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D15
  • Cause of death: ICD-10 D15

2 out of 7 registries used, show all original rules.

291

4. Check minimum number of events

None

291

5. Include endpoints

340

6. Filter based on genotype QC (FinnGen only)

323

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Neoplasmata benigna organorum endothoracicorum aliorum sive non specificatorum

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2498 1388 1085
Only index persons 2049 1198 851
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 54.47 56.23 51.98
Only index persons 52.89 55.50 49.23

-FinnGen-

Key figures

All Female Male
Number of individuals 323 172 151
Unadjusted period prevalence (%) 0.07 0.07 0.08
Median age at first event (years) 56.09 55.68 56.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_INTRATHORACIC and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_INTRATHORACIC 1.723 [1.35, 2.2] < 0.001
Birth year 0.99 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 170 out of 792 females with CD2_BENIGN_INTRATHORACIC died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_INTRATHORACIC 1.914 [1.5, 2.44] < 0.001
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 144 out of 631 males with CD2_BENIGN_INTRATHORACIC died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_INTRATHORACIC.

N-year risk Females Males
1 0.14% 0.406%
5 0.988% 2.501%
10 2.339% 6.167%
15 4.24% 11.267%
20 7.286% 18.197%

Relationships between endpoints

Index endpoint: CD2_BENIGN_INTRATHORACIC – Benign neoplasm of other and unspecified intrathoracic organs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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