Benign neoplasm of breast

CD2_BENIGN_BREAST

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D24&
  • Hospital discharge: ICD-9 217
  • Hospital discharge: ICD-8 21799
  • Cause of death: ICD-10 D24&
  • Cause of death: ICD-9 217
  • Cause of death: ICD-8 21799

2 out of 7 registries used, show all original rules.

4473

4. Check minimum number of events

None

4473

5. Include endpoints

None

4473

6. Filter based on genotype QC (FinnGen only)

4271

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Neoplasma benignum mammae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36691 36691 -
Only index persons 33454 33454 -
Unadjusted period prevalence (%)
Whole population 1.05 1.05 -
Only index persons 1.23 1.23 -
Median age at first event (years)
Whole population - 43.94 -
Only index persons - 42.89 -

-FinnGen-

Key figures

All Female Male
Number of individuals 4271 4271 -
Unadjusted period prevalence (%) 1.68 1.68 -
Median age at first event (years) 42.54 42.54 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BREAST and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BREAST 1.045 [0.95, 1.15] 0.36
Birth year 0.999 [0.99, 1.01] 0.807

During the follow-up period (1.1.1998 — 31.12.2019), 1574 out of 17928 females with CD2_BENIGN_BREAST died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BREAST.

N-year risk Females Males
1 0.102% No data
5 0.61% No data
10 1.804% No data
15 3.457% No data
20 6.259% No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_BREAST – Benign neoplasm of breast

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data