extra-adrenal sympathetic paraganglioma: A benign or malignant sympathetic paraganglioma arising from paraganglia outside the adrenal gland. Clinical symptoms are related to secretion of catecholamines. Representative examples include the superior and inferior paraaortic and bladder paragangliomas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2334 |
4. Check minimum number of eventsNone |
2334 |
5. Include endpointsNone |
2334 |
6. Filter based on genotype QC (FinnGen only) |
2238 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D35
Name in latin
Neoplasma benignum glandulae suprarenalis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Adrenal gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Adrenal gland
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12586 | 7260 | 5280 |
| Only index persons | 12040 | 7010 | 5030 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.15 |
| Only index persons | 0.23 | 0.26 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 63.85 | 63.72 | 64.13 |
| Only index persons | 63.88 | 63.69 | 64.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2238 | 1297 | 941 |
| Unadjusted period prevalence (%) | 0.49 | 0.51 | 0.47 |
| Median age at first event (years) | 63.42 | 61.76 | 65.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_ADRENAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ADRENAL | 1.647 [1.44, 1.89] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 815 out of 5459 females with CD2_BENIGN_ADRENAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ADRENAL | 1.624 [1.4, 1.88] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 823 out of 4080 males with CD2_BENIGN_ADRENAL died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_ADRENAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.128% | 0.353% |
| 5 | 0.798% | 1.877% |
| 10 | 2.077% | 4.48% |
| 15 | 3.984% | 8.262% |
| 20 | 6.997% | 14.096% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_ADRENAL – Benign neoplasm: Adrenal gland
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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