No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Papillary adenocarcinoma of thyroid gland
based on the number of shared cases.
Similar with more cases:
- Papillary adenocarcinoma of thyroid gland
- Malignant neoplasm of thyroid gland
- Malignant neoplasm of thyroid gland
- Malignant neoplasm of endocrine gland
- Malignant neoplasm of endocrine gland
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10847 | 8351 | 2412 |
| Only index persons | 9523 | 7488 | 2035 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.24 | 0.07 |
| Only index persons | 0.23 | 0.28 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 49.55 | 48.74 | 52.35 |
| Only index persons | 48.19 | 47.48 | 50.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1741 | 1317 | 424 |
| Unadjusted period prevalence (%) | 0.44 | 0.52 | 0.21 |
| Median age at first event (years) | 49.37 | 47.16 | 56.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_THYROID_PAPILLARY_ADENO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_THYROID_PAPILLARY_ADENO_EXALLC | 1.149 [1.01, 1.31] | 0.034 |
| Birth year | 0.998 [0.99, 1.01] | 0.657 |
During the follow-up period (1.1.1998 — 31.12.2019), 465 out of 4850 females with C3_THYROID_PAPILLARY_ADENO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_THYROID_PAPILLARY_ADENO_EXALLC | 1.474 [1.24, 1.75] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 284 out of 1497 males with C3_THYROID_PAPILLARY_ADENO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_THYROID_PAPILLARY_ADENO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.297% |
| 5 | 0.796% | 1.577% |
| 10 | 1.746% | 3.823% |
| 15 | 3.459% | 7.362% |
| 20 | 6.536% | 12.578% |
Relationships between endpoints
↥Index endpoint: C3_THYROID_PAPILLARY_ADENO_EXALLC – Papillary adenocarcinoma of thyroid gland
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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