No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Follicular adenocarcinoma of thyroid gland
based on the number of shared cases.
Similar with more cases:
- Follicular adenocarcinoma of thyroid gland
- Malignant neoplasm of thyroid gland
- Malignant neoplasm of thyroid gland
- Malignant neoplasm of endocrine gland
- Malignant neoplasm of endocrine gland
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1861 | 1296 | 538 |
| Only index persons | 1230 | 891 | 339 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.97 | 54.66 | 59.24 |
| Only index persons | 52.01 | 50.23 | 56.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 195 | 120 | 75 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | 50.33 | 47.16 | 55.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_THYROID_FOLLICULAR_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_THYROID_FOLLICULAR_EXALLC | 1.714 [1.37, 2.15] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.308 |
During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 560 females with C3_THYROID_FOLLICULAR_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_THYROID_FOLLICULAR_EXALLC | 2.821 [1.98, 4.03] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 272 males with C3_THYROID_FOLLICULAR_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_THYROID_FOLLICULAR_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.526% |
| 5 | 0.987% | 3.253% |
| 10 | 2.483% | 8.249% |
| 15 | 4.862% | 15.028% |
| 20 | 8.199% | 24.553% |
Relationships between endpoints
↥Index endpoint: C3_THYROID_FOLLICULAR_EXALLC – Follicular adenocarcinoma of thyroid gland
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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