No definition available.
Squamous cell neoplasms and carcinomas of the skin
C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Squamous cell neoplasms and carcinomas of the skin
based on the number of shared cases.
Similar with more cases:
- Squamous cell neoplasms and carcinomas of the skin
- Malignant neoplasm, wide definition for exclusion
- Malignant neoplasm, wide definition for exclusion
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 41339 | 19341 | 21596 |
| Only index persons | 33376 | 16018 | 17358 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.58 | 0.55 | 0.60 |
| Only index persons | 0.63 | 0.59 | 0.66 |
| Median age at first event (years) | |||
| Whole population | 78.18 | 79.88 | 76.72 |
| Only index persons | 78.38 | 79.88 | 77.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4078 | 1506 | 2572 |
| Unadjusted period prevalence (%) | 1.03 | 0.59 | 1.29 |
| Median age at first event (years) | 75.11 | 74.24 | 75.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC | 1.184 [1.06, 1.32] | 0.002 |
| Birth year | 0.996 [0.99, 1.0] | 0.305 |
During the follow-up period (1.1.1998 — 31.12.2019), 6869 out of 14677 females with C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC | 1.193 [1.06, 1.34] | 0.004 |
| Birth year | 0.989 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 7385 out of 15926 males with C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.275% |
| 5 | 0.731% | 1.66% |
| 10 | 1.81% | 4.051% |
| 15 | 3.451% | 7.395% |
| 20 | 5.89% | 12.111% |
Relationships between endpoints
↥Index endpoint: C3_SQUOMOUS_CELL_CARCINOMA_SKIN_EXALLC – Squamous cell neoplasms and carcinomas of the skin
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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