No definition available.
Neuroendocrine tumor and carcinoma of small intestine
C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Neuroendocrine tumor and carcinoma of small intestine
based on the number of shared cases.
Similar with more cases:
- Neuroendocrine tumor and carcinoma of small intestine
- Malignant neoplasm of small intestine
- Malignant neoplasm of small intestine
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2013 | 906 | 1078 |
| Only index persons | 1543 | 723 | 820 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.45 | 65.94 | 65.01 |
| Only index persons | 65.12 | 65.42 | 64.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 410 | 198 | 212 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.11 |
| Median age at first event (years) | 62.80 | 61.09 | 64.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC | 2.489 [1.93, 3.22] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.529 |
During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 616 females with C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC | 2.678 [2.08, 3.45] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 287 out of 747 males with C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.251% | 0.392% |
| 5 | 1.451% | 2.6% |
| 10 | 3.394% | 7.285% |
| 15 | 7.384% | 13.646% |
| 20 | 12.983% | 22.83% |
Relationships between endpoints
↥Index endpoint: C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC – Neuroendocrine tumor and carcinoma of small intestine
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data