No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Adenocarcinoma of small intestine
based on the number of shared cases.
Similar with more cases:
- Adenocarcinoma of small intestine
- Malignant neoplasm of small intestine
- Malignant neoplasm of small intestine
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 982 | 425 | 537 |
| Only index persons | 555 | 249 | 306 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 67.59 | 67.19 | 67.87 |
| Only index persons | 68.43 | 67.19 | 69.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 82 | 33 | 49 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 69.65 | 65.83 | 72.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_SMALL_INTESTINE_ADENO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SMALL_INTESTINE_ADENO_EXALLC | 7.932 [4.73, 13.3] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.624 |
During the follow-up period (1.1.1998 — 31.12.2019), 175 out of 271 females with C3_SMALL_INTESTINE_ADENO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SMALL_INTESTINE_ADENO_EXALLC | 5.814 [3.51, 9.64] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 317 males with C3_SMALL_INTESTINE_ADENO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_SMALL_INTESTINE_ADENO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.88% | 1.062% |
| 5 | 4.673% | 6.154% |
| 10 | 12.461% | 15.468% |
| 15 | 21.632% | 28.029% |
| 20 | 35.721% | 44.716% |
Relationships between endpoints
↥Index endpoint: C3_SMALL_INTESTINE_ADENO_EXALLC – Adenocarcinoma of small intestine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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