Endometroid carcinoma of ovary

C3_OVARY_ENDOMETROID_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C56.73&
  • Cause of death: ICD-10 C56.73&
  • Cancer registry: Topography ICD-O-3 C56
  • Cancer registry: Morphology ICD-O-3 8380
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3261 3261 -
Only index persons 1668 1668 -
Unadjusted period prevalence (%)
Whole population 0.09 0.09 -
Only index persons 0.06 0.06 -
Median age at first event (years)
Whole population - 60.58 -
Only index persons - 59.34 -

-FinnGen-

Key figures

All Female Male
Number of individuals 273 273 -
Unadjusted period prevalence (%) 0.11 0.11 -
Median age at first event (years) 60.38 60.38 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint C3_OVARY_ENDOMETROID_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_OVARY_ENDOMETROID_EXALLC 4.824 [4.09, 5.69] < 0.001
Birth year 0.993 [0.98, 1.0] 0.114

During the follow-up period (1.1.1998 — 31.12.2019), 920 out of 1695 females with C3_OVARY_ENDOMETROID_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have C3_OVARY_ENDOMETROID_EXALLC.

N-year risk Females Males
1 0.388% No data
5 2.874% No data
10 6.852% No data
15 13.06% No data
20 20.973% No data

Relationships between endpoints

Index endpoint: C3_OVARY_ENDOMETROID_EXALLC – Endometroid carcinoma of ovary

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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