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Non-Hodgkin lymphoma, all

Endpoint Browser PheWeb

C3_NONHODGKIN_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C82, C83, C84, C85
  • Cause of death: ICD-9 — 200
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 967[0-9]|970[0-2]
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18146 8018 9686
Only index persons 8756 3843 4913
Unadjusted period prevalence (%)
Whole population 0.26 0.23 0.27
Only index persons 0.17 0.14 0.19
Median age at first event (years)
Whole population 72.37 74.22 70.95
Only index persons 74.18 75.99 72.77

-FinnGen-

Key figures

All Female Male
Number of individuals 1196 381 815
Unadjusted period prevalence (%) 0.33 0.15 0.41
Median age at first event (years) 70.94 69.50 71.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_NONHODGKIN_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_NONHODGKIN_EXALLC 3.9 [3.18, 4.79] < 0.001
Birth year 0.994 [0.99, 1.0] 0.165

During the follow-up period (1.1.1998 — 31.12.2019), 588 out of 1250 females with C3_NONHODGKIN_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_NONHODGKIN_EXALLC 2.908 [2.43, 3.48] < 0.001
Birth year 0.989 [0.98, 1.0] 0.025

During the follow-up period (1.1.1998 — 31.12.2019), 1028 out of 2037 males with C3_NONHODGKIN_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_NONHODGKIN_EXALLC.

N-year risk Females Males
1 0.316% 0.695%
5 1.899% 3.977%
10 5.015% 8.713%
15 9.9% 16.252%
20 16.585% 27.513%

Relationships between endpoints

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Index endpoint: C3_NONHODGKIN_EXALLC – Non-Hodgkin lymphoma, all

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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