No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Multiple myeloma
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11460 | 5512 | 5712 |
| Only index persons | 5568 | 2719 | 2849 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | 0.16 |
| Only index persons | 0.10 | 0.10 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 70.36 | 71.38 | 69.46 |
| Only index persons | 71.38 | 72.60 | 70.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 787 | 345 | 442 |
| Unadjusted period prevalence (%) | 0.18 | 0.14 | 0.22 |
| Median age at first event (years) | 69.71 | 69.09 | 70.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_MULT_MYELOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MULT_MYELOMA_EXALLC | 8.551 [7.03, 10.41] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2250 out of 3154 females with C3_MULT_MYELOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MULT_MYELOMA_EXALLC | 5.653 [4.61, 6.93] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 2312 out of 3205 males with C3_MULT_MYELOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_MULT_MYELOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.628% | 1.098% |
| 5 | 4.16% | 6.75% |
| 10 | 9.659% | 15.708% |
| 15 | 16.995% | 28.128% |
| 20 | 28.598% | 45.401% |
Relationships between endpoints
↥Index endpoint: C3_MULT_MYELOMA_EXALLC – Multiple myeloma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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