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Brain meningioma

Endpoint Browser PheWeb

C3_MENINGIOMA_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C70
  • Cause of death: ICD-9 — 1921|1923
  • Cause of death: ICD-8 — 192[1-2]
  • Cancer registry: Topography ICD-O-3 — C70
  • Cancer registry: Morphology ICD-O-3 — 953[0-4]|953[7-9]
  • Cancer registry: Behaviour codes — ANY

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12584 9165 3290
Only index persons 9814 7446 2368
Unadjusted period prevalence (%)
Whole population 0.22 0.26 0.09
Only index persons 0.23 0.27 0.09
Median age at first event (years)
Whole population 59.77 59.48 60.56
Only index persons 58.74 58.41 59.76

-FinnGen-

Key figures

All Female Male
Number of individuals 1605 1202 403
Unadjusted period prevalence (%) 0.40 0.47 0.20
Median age at first event (years) 58.68 57.70 61.58

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_MENINGIOMA_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_MENINGIOMA_EXALLC 1.399 [1.27, 1.55] < 0.001
Birth year 0.995 [0.99, 1.0] 0.282

During the follow-up period (1.1.1998 — 31.12.2019), 1134 out of 5670 females with C3_MENINGIOMA_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_MENINGIOMA_EXALLC 1.352 [1.18, 1.55] < 0.001
Birth year 0.991 [0.98, 1.0] 0.058

During the follow-up period (1.1.1998 — 31.12.2019), 519 out of 1887 males with C3_MENINGIOMA_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_MENINGIOMA_EXALLC.

N-year risk Females Males
1 0.093% 0.337%
5 0.771% 1.832%
10 2.014% 4.652%
15 3.982% 8.684%
20 7.059% 14.621%

Relationships between endpoints

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Index endpoint: C3_MENINGIOMA_EXALLC – Brain meningioma

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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