No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Mantle cell lymphoma
based on the number of shared cases.
Similar with more cases:
- Mantle cell lymphoma
- Non-follicular lymphoma
- Non-follicular lymphoma
- Primary_lymphoid and hematopoietic malignant neoplasms
- Primary_lymphoid and hematopoietic malignant neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1774 | 517 | 1236 |
| Only index persons | 1372 | 399 | 973 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.01 | 0.03 |
| Only index persons | 0.03 | 0.01 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 71.76 | 73.96 | 70.88 |
| Only index persons | 71.20 | 72.58 | 70.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 267 | 56 | 211 |
| Unadjusted period prevalence (%) | 0.09 | 0.02 | 0.11 |
| Median age at first event (years) | 70.14 | 68.27 | 70.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_MANTLE_CELL_LYMPHOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MANTLE_CELL_LYMPHOMA_EXALLC | 4.62 [3.17, 6.74] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.202 |
During the follow-up period (1.1.1998 — 31.12.2019), 196 out of 385 females with C3_MANTLE_CELL_LYMPHOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MANTLE_CELL_LYMPHOMA_EXALLC | 3.244 [2.52, 4.18] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 442 out of 868 males with C3_MANTLE_CELL_LYMPHOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_MANTLE_CELL_LYMPHOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.429% | 0.782% |
| 5 | 2.415% | 3.523% |
| 10 | 5.836% | 8.743% |
| 15 | 11.543% | 16.474% |
| 20 | 20.221% | 27.606% |
Relationships between endpoints
↥Index endpoint: C3_MANTLE_CELL_LYMPHOMA_EXALLC – Mantle cell lymphoma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data