No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Hepatocellular carcinoma
based on the number of shared cases.
Similar with more cases:
- Hepatocellular carcinoma
- Malignant neoplasm of liver and intrahepatic bile ducts
- Malignant neoplasm of liver and intrahepatic bile ducts
- Malignant neoplasm of intrahepatic ducts, biliary tract and gallbladder
- Malignant neoplasm of biliary tract and gallbladder
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8051 | 2133 | 5659 |
| Only index persons | 4242 | 1061 | 3181 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.06 | 0.16 |
| Only index persons | 0.10 | 0.04 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 71.73 | 74.61 | 70.78 |
| Only index persons | 72.89 | 76.49 | 71.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 609 | 75 | 534 |
| Unadjusted period prevalence (%) | 0.24 | 0.03 | 0.27 |
| Median age at first event (years) | 73.06 | 74.48 | 72.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_HEPATOCELLU_CARC_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_HEPATOCELLU_CARC_EXALLC | 15.451 [9.31, 25.64] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.236 |
During the follow-up period (1.1.1998 — 31.12.2019), 711 out of 850 females with C3_HEPATOCELLU_CARC_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_HEPATOCELLU_CARC_EXALLC | 13.507 [9.17, 19.9] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 2072 out of 2537 males with C3_HEPATOCELLU_CARC_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_HEPATOCELLU_CARC_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.455% | 2.265% |
| 5 | 8.285% | 12.575% |
| 10 | 21.229% | 31.733% |
| 15 | 36.328% | 52.392% |
| 20 | 54.706% | 71.723% |
Relationships between endpoints
↥Index endpoint: C3_HEPATOCELLU_CARC_EXALLC – Hepatocellular carcinoma
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data