No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Control conditions
not HLP_C3_CLL
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Chronic lymphocytic leukaemia
based on the number of shared cases.
Similar with more cases:
- Chronic lymphocytic leukaemia
- Chronic lymphocytic leukaemia
- Any event in cancer register
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8468 | 3276 | 5047 |
| Only index persons | 5092 | 2091 | 3001 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.09 | 0.14 |
| Only index persons | 0.10 | 0.08 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 69.99 | 71.38 | 69.13 |
| Only index persons | 69.99 | 70.88 | 69.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 851 | 291 | 560 |
| Unadjusted period prevalence (%) | 0.22 | 0.11 | 0.28 |
| Median age at first event (years) | 68.60 | 68.23 | 68.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_CLL_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_CLL_EXALLC | 2.582 [2.23, 2.99] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.208 |
During the follow-up period (1.1.1998 — 31.12.2019), 949 out of 2030 females with C3_CLL_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_CLL_EXALLC | 2.719 [2.32, 3.18] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1577 out of 3119 males with C3_CLL_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_CLL_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.297% | 0.475% |
| 5 | 1.577% | 2.949% |
| 10 | 3.623% | 7.671% |
| 15 | 6.873% | 14.293% |
| 20 | 11.991% | 22.671% |
Relationships between endpoints
↥Index endpoint: C3_CLL_EXALLC – Chronic lymphocytic leukaemia
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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