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Acute lymphocytic leukaemia

Endpoint Browser PheWeb

C3_ALL_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_ALL
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C91.0
  • Cause of death: ICD-9 — 2040A
  • Cause of death: ICD-8 — 20400
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 981[1-8]|9835
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_ALL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3167 1432 1713
Only index persons 1750 850 900
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.05
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 11.29 9.66 12.08
Only index persons 8.20 7.38 8.98

-FinnGen-

Key figures

All Female Male
Number of individuals 214 122 92
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 9.23 7.25 11.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_ALL_EXALLC and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
C3_ALL_EXALLC 14.683 [7.47, 28.86] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 202 out of 722 males with C3_ALL_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_ALL_EXALLC.

N-year risk Females Males
1 No data 2.875%
5 No data 14.801%
10 No data 34.919%
15 No data 55.724%
20 No data 75.5%

Relationships between endpoints

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Index endpoint: C3_ALL_EXALLC – Acute lymphocytic leukaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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