No definition available.
Anaphylactic shock due to adverse effect of correct drug or medication properly administered
ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
382 |
4. Check minimum number of eventsNone |
382 |
5. Include endpointsNone |
382 |
6. Filter based on genotype QC (FinnGen only) |
368 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Anaphylactic shock due to adverse effect of correct drug or medication properly administered
based on the number of shared cases.
Similar with more cases:
- Other complications of surgical and medical care, not elsewhere classified
- Complications of surgical and medical care, not elsewhere classified
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2507 | 1626 | 859 |
| Only index persons | 2350 | 1557 | 793 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.79 | 51.85 | 51.61 |
| Only index persons | 51.56 | 51.44 | 51.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 368 | 259 | 109 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.05 |
| Median age at first event (years) | 53.44 | 50.95 | 59.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE | 2.664 [2.09, 3.4] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.195 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 1378 females with ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE | 2.263 [1.67, 3.07] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 723 males with ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE died.
Mortality risk
Mortality risk for people of age
years, who have ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.262% | 0.476% |
| 5 | 1.442% | 2.752% |
| 10 | 3.806% | 6.509% |
| 15 | 7.505% | 12.835% |
| 20 | 12.907% | 22.173% |
Relationships between endpoints
↥Index endpoint: ANAPH_SHOCK_ADVER_EFFECT_CORRE_DRUG_MEDICAM_PROPE_ADMINISTE – Anaphylactic shock due to adverse effect of correct drug or medication properly administered
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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