Pinta: An infectious disease of the skin caused by Treponema carateum that occurs only in the western hemisphere. Age of onset is between 10 and 20 years of age. This condition is characterized by marked changes in the skin color and is believed to be transmitted by direct person-to-person contact.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
2940 |
6. Filter based on genotype QC (FinnGen only) |
2810 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other spirochaetal diseases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22507 | 12132 | 10305 |
| Only index persons | 20424 | 11128 | 9296 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.32 | 0.35 | 0.29 |
| Only index persons | 0.38 | 0.41 | 0.35 |
| Median age at first event (years) | |||
| Whole population | 50.68 | 51.77 | 49.40 |
| Only index persons | 52.33 | 53.27 | 51.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2810 | 1684 | 1126 |
| Unadjusted period prevalence (%) | 0.62 | 0.66 | 0.57 |
| Median age at first event (years) | 58.51 | 56.53 | 61.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_OTHER_SPIROCHAETAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_OTHER_SPIROCHAETAL | 0.855 [0.75, 0.98] | 0.025 |
| Birth year | 0.992 [0.98, 1.0] | 0.08 |
During the follow-up period (1.1.1998 — 31.12.2019), 579 out of 9498 females with AB1_OTHER_SPIROCHAETAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_OTHER_SPIROCHAETAL | 0.869 [0.75, 1.0] | 0.056 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 665 out of 8102 males with AB1_OTHER_SPIROCHAETAL died.
Mortality risk
Mortality risk for people of age
years, who have AB1_OTHER_SPIROCHAETAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.079% | 0.153% |
| 5 | 0.478% | 1.001% |
| 10 | 1.159% | 2.406% |
| 15 | 2.151% | 4.76% |
| 20 | 3.815% | 8.105% |
Relationships between endpoints
↥Index endpoint: AB1_OTHER_SPIROCHAETAL – Other spirochaetal diseases
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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