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Other infectious diseases

DOID EFO Endpoint Browser PheWeb

AB1_OTHER_INFECTIONS

infectious disease: A disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B99
  • Hospital discharge: ICD-9 — 136[8-9]
  • Hospital discharge: ICD-8 — 1360[8-9]
  • Cause of death: ICD-10 — B99
  • Cause of death: ICD-9 — 136[8-9]
  • Cause of death: ICD-8 — 1360[8-9]

2 out of 7 registries used, show all original rules.

2877

4. Check minimum number of events

None

2877

5. Include endpoints

None

2877

6. Filter based on genotype QC (FinnGen only)

2745

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 B99-B99
Name in latin Morbi infectiosi alii et non specificati

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30118 14298 15550
Only index persons 25362 12247 13115
Unadjusted period prevalence (%)
Whole population 0.42 0.41 0.43
Only index persons 0.48 0.45 0.50
Median age at first event (years)
Whole population 65.84 66.85 64.81
Only index persons 64.46 65.47 63.51

-FinnGen-

Key figures

All Female Male
Number of individuals 2745 1330 1415
Unadjusted period prevalence (%) 0.62 0.52 0.71
Median age at first event (years) 60.98 55.81 65.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_OTHER_INFECTIONS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_INFECTIONS 2.899 [2.57, 3.27] < 0.001
Birth year 0.995 [0.99, 1.0] 0.203

During the follow-up period (1.1.1998 — 31.12.2019), 5152 out of 11728 females with AB1_OTHER_INFECTIONS died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_INFECTIONS 3.052 [2.66, 3.49] < 0.001
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 5986 out of 12760 males with AB1_OTHER_INFECTIONS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_INFECTIONS.

N-year risk Females Males
1 0.244% 0.699%
5 1.528% 3.358%
10 4.186% 7.93%
15 8.183% 15.529%
20 14.109% 25.974%

Relationships between endpoints

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Index endpoint: AB1_OTHER_INFECTIONS – Other infectious diseases

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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