Unspecified human immunodeficiency virus [HIV] disease

AB1_HIV_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B24
  • Hospital discharge: ICD-9 0788A|0788B|0788C
  • Cause of death: ICD-10 B24
  • Cause of death: ICD-9 0788A|0788B|0788C

2 out of 7 registries used, show all original rules.

323

4. Check minimum number of events

None

323

5. Include endpoints

None

323

6. Filter based on genotype QC (FinnGen only)

265

Control definitions (FinnGen only)

Control exclude AB1_HIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2230 539 1557
Only index persons 1747 492 1255
Unadjusted period prevalence (%)
Whole population 0.04 0.02 0.04
Only index persons 0.04 0.02 0.05
Median age at first event (years)
Whole population 39.14 34.60 41.16
Only index persons 39.53 34.14 41.64

-FinnGen-

Key figures

All Female Male
Number of individuals 265 44 221
Unadjusted period prevalence (%) 0.10 0.02 0.11
Median age at first event (years) 41.64 40.63 41.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_HIV_NOS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_HIV_NOS 3.161 [2.63, 3.81] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 1214 males with AB1_HIV_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HIV_NOS.

N-year risk Females Males
1 No data 0.477%
5 No data 3.193%
10 No data 8.646%
15 No data 14.951%
20 No data 24.987%

Relationships between endpoints

Index endpoint: AB1_HIV_NOS – Unspecified human immunodeficiency virus [HIV] disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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