Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

AB1_HIV_INFECT_PARASITES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B20
  • Cause of death: ICD-10 B20

2 out of 7 registries used, show all original rules.

79

4. Check minimum number of events

None

79

5. Include endpoints

None

79

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Control exclude AB1_HIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 721 224 457
Only index persons 565 193 372
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 43.20 40.28 45.11
Only index persons 43.37 39.02 45.63

-FinnGen-

Key figures

All Female Male
Number of individuals 66 16 50
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 47.81 54.03 45.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint AB1_HIV_INFECT_PARASITES and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_HIV_INFECT_PARASITES 4.062 [2.74, 6.01] < 0.001
Birth year 0.991 [0.98, 1.0] 0.052

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 367 males with AB1_HIV_INFECT_PARASITES died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HIV_INFECT_PARASITES.

N-year risk Females Males
1 No data 0.694%
5 No data 4.927%
10 No data 12.343%
15 No data 22.69%
20 No data 36.882%

Relationships between endpoints

Index endpoint: AB1_HIV_INFECT_PARASITES – Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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