Trematode Infections: Infections caused by infestation with worms of the class Trematoda.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
562 |
4. Check minimum number of eventsNone |
562 |
5. Include endpoints
|
600 |
6. Filter based on genotype QC (FinnGen only) |
562 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF6V3
Helminthiases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8913 | 4944 | 3842 |
| Only index persons | 5959 | 3558 | 2401 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.11 |
| Only index persons | 0.12 | 0.13 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 33.97 | 31.17 | 37.09 |
| Only index persons | 29.01 | 28.92 | 29.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 562 | 342 | 220 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.11 |
| Median age at first event (years) | 36.45 | 33.41 | 41.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint AB1_HELMINTIASES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_HELMINTIASES | 1.881 [1.47, 2.4] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 2014 females with AB1_HELMINTIASES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_HELMINTIASES | 2.493 [2.0, 3.1] | < 0.001 |
| Birth year | 0.98 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 1494 males with AB1_HELMINTIASES died.
Mortality risk
Mortality risk for people of age
years, who have AB1_HELMINTIASES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.394% |
| 5 | 0.95% | 2.228% |
| 10 | 2.608% | 5.756% |
| 15 | 4.979% | 11.009% |
| 20 | 8.444% | 18.296% |
Relationships between endpoints
↥Index endpoint: AB1_HELMINTIASES – Helminthiases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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